Dr. Downs is fantastic. He is very knowledgeable and communicates very effectively. The staff made this experience comfortable for me. I am very happy and pleased with the results.
Finally, a Real Solution for Weight Loss!
Discover a long-term weight loss solution with The Centre Core Program. Utilizing highly effective medications, Semaglutide and Tirzepatide, this program is designed to help you comfortably lose 2–3 pounds per week under the expert care of The Centre, P.C.’s providers.
Are you ready to take the first step? Schedule your consultation for just $50! Labs are required before starting treatment and after one month of use to optimize your results. Additional fees are required for lab work.

What Are Semaglutide & Tirzepatide?
Semaglutide and Tirzepatide mimic glucagon-like peptide-1 (GLP-1), a hormone naturally produced by your body after eating. These medications:
- Increase satiety: Helping you feel full longer.
- Regulate blood sugar: Reducing cravings.
- Slow digestion: Sustaining feelings of fullness.
Under professional supervision, patients may lose 15–20% of their body weight and maintain results long-term!


Benefits of Semaglutide & Tirzepatide Treatments
- Effective Weight Loss: Lose 2–3 pounds weekly.
- Long-Term Results: Sustain your progress with expert support.
- Convenient Administration: Weekly self-injections fit into any lifestyle.
- Personalized Care: Tailored plans ensure safety and success.
Who Is a Good Candidate?
This program may be ideal for you if you:
- Have a BMI over 27 with related health concerns or over 30 without.
- Struggle with weight management despite diet and exercise.
- Are committed to following a personalized weight loss plan.
Your provider will assess your overall health to determine if this program is a safe option.


The Procedure Process
Initial Consultation
Meet with our provider to discuss your health history, current medications, weight goals, and allergies. Labs will be reviewed to ensure you're ready to begin.
Treatment Plan
Receive a customized plan tailored to your needs. Learn how to administer weekly injections with detailed guidance from our team.
Ongoing Support
Meet monthly with your provider to evaluate progress and adjust your dosage if necessary.
Lifestyle Changes
Implement minor dietary and lifestyle adjustments to maximize results while managing potential side effects.

Recovery and Aftercare
Patients experience minimal downtime with Semaglutide and Tirzepatide. Some side effects, such as nausea or bloating, may occur during dosage adjustments but are typically manageable. Our team provides continuous support to ensure you remain comfortable throughout your journey.Results
Patients report visible weight loss within 4 weeks, with continued results of 2–3 pounds weekly. Over time, many achieve a 15–20% reduction in body weight, enhancing their health and confidence.


Dr. Macias and her staff helped make this very personal decision easy and comfortable. They took the time to listen and answered all my questions. I was very nervous about having breast surgery but after it was done I was so happy with the results. She truly nailed it. I would highly recommend Dr. Macias to anyone considering any cosmetic surgery.
Everyone here is so kind, helpful, talented and caring.I trust highly in them and will always come to them for all my cosmetic concerns and care!!❤️
I recently had a surgical procedure done with Dr. Macias. The staff was absolutely amazing from my consult to surgery everyone was soooo sweet and kind! So very helpful from the front desk to the treatment coordinators to the pre op the whole surgery experience to post op!!
If you are considering on having anything done I highly recommend. I am extremely happy with my results so far and it’s only been a week.
I had a great experience here, the staff are so friendly and make you feel comfortable. Dr. Downs is the best, I will definitely be returning.
I received a rhinoplasty from Dr. Macias and my nose is PERFECT. 😍
I enjoyed my whole experience but here are a few specific highlights that stuck out:
- The staff is kind, informative, and responds quickly.
- I loved the simulation they used to show desired results.
- The staff the day of surgery was fun and helped me with my nerves.
- From the little shopping I did, their prices were the best (sometimes by far!).
Dr. Macias and her staff helped make this very personal decision easy and comfortable. They took the time to listen and answered all my questions. I was very nervous about having breast surgery but after it was done I was so happy with the results. She truly nailed it. I would highly recommend Dr. Macias to anyone considering any cosmetic surgery.
Dr. Downs and whole team at Centre PC have been amazing! They listened to me as I told them my desired results, provided different options for me, based on years of industry knowledge and worked alongside me as I navigated the headaches of insurance. I couldn’t be happier with my experience there and would highly recommend them to anyone looking to make some positive change in their life!
I was recently hospitalized last week for a finger infection. I ended up having surgery and Dr. Downs was my doctor. Very good bedside manner and great doctor. He takes his time to explain things to you. I really liked that. And went to his office for my follow up. All the staff were so sweet and professional.
I was referred to The Centre by the on call hand Doctor that reviewed my ER case after I split my thumb open. From setting up my appointment to being taken care of by the staff, it was a pleasant experience. Each member of the team I met was attentive, very forthright with any information I needed & were an absolute pleasure to be around. Dr. Downs has an amazing staff!
Dr. Downs is fantastic. He is very knowledgeable and communicates very effectively. The staff made this experience comfortable for me. I am very happy and pleased with the results.
I’ve been going to the Spa for a few years now and have always had a positive experience with my services and staff. Everyone is always kind and informative. Ashley Kweder has easily been my favorite cosmetic injector! She has always been able execute everything I wanted, keeping me well informed and being absolutely the sweetest! Highly recommend
Frequently Asked Questions
About Weight Loss Program in Mishawaka, IN
Treatment duration varies based on your goals, but most patients continue until they achieve their desired weight and transition to a maintenance plan.
Yes, minor dietary and activity adjustments enhance results and minimize side effects.
Your provider will review your current medications to ensure there are no conflicts.

