Everyone here is so kind, helpful, talented and caring.I trust highly in them and will always come to them for all my cosmetic concerns and care!!❤️
Finally, a Real Solution for Weight Loss!
Discover a long-term weight loss solution with The Centre Core Program. Utilizing highly effective medications, Semaglutide and Tirzepatide, this program is designed to help you comfortably lose 2–3 pounds per week under the expert care of The Centre, P.C.’s providers.
Are you ready to take the first step? Schedule your consultation for just $50! Labs are required before starting treatment and after one month of use to optimize your results. Additional fees are required for lab work.

What Are Semaglutide & Tirzepatide?
Semaglutide and Tirzepatide mimic glucagon-like peptide-1 (GLP-1), a hormone naturally produced by your body after eating. These medications:
- Increase satiety: Helping you feel full longer.
- Regulate blood sugar: Reducing cravings.
- Slow digestion: Sustaining feelings of fullness.
Under professional supervision, patients may lose 15–20% of their body weight and maintain results long-term!


Benefits of Semaglutide & Tirzepatide Treatments
- Effective Weight Loss: Lose 2–3 pounds weekly.
- Long-Term Results: Sustain your progress with expert support.
- Convenient Administration: Weekly self-injections fit into any lifestyle.
- Personalized Care: Tailored plans ensure safety and success.
Who Is a Good Candidate?
This program may be ideal for you if you:
- Have a BMI over 27 with related health concerns or over 30 without.
- Struggle with weight management despite diet and exercise.
- Are committed to following a personalized weight loss plan.
Your provider will assess your overall health to determine if this program is a safe option.


The Procedure Process
Initial Consultation
Meet with our provider to discuss your health history, current medications, weight goals, and allergies. Labs will be reviewed to ensure you're ready to begin.
Treatment Plan
Receive a customized plan tailored to your needs. Learn how to administer weekly injections with detailed guidance from our team.
Ongoing Support
Meet monthly with your provider to evaluate progress and adjust your dosage if necessary.
Lifestyle Changes
Implement minor dietary and lifestyle adjustments to maximize results while managing potential side effects.

Recovery and Aftercare
Patients experience minimal downtime with Semaglutide and Tirzepatide. Some side effects, such as nausea or bloating, may occur during dosage adjustments but are typically manageable. Our team provides continuous support to ensure you remain comfortable throughout your journey.Results
Patients report visible weight loss within 4 weeks, with continued results of 2–3 pounds weekly. Over time, many achieve a 15–20% reduction in body weight, enhancing their health and confidence.


Dr. Macias is AMAZING!! She is so caring and kind. She listens to her patients and seems to really love her job and cares about her patients. I would highly recommend her. Her staff also has been very wonderful and caring all the time!
Dr. Downs is fantastic. He is very knowledgeable and communicates very effectively. The staff made this experience comfortable for me. I am very happy and pleased with the results.
I had a great experience here, the staff are so friendly and make you feel comfortable. Dr. Downs is the best, I will definitely be returning.
Dr. Macias and her staff helped make this very personal decision easy and comfortable. They took the time to listen and answered all my questions. I was very nervous about having breast surgery but after it was done I was so happy with the results. She truly nailed it. I would highly recommend Dr. Macias to anyone considering any cosmetic surgery.
I recently had a surgical procedure done with Dr. Macias. The staff was absolutely amazing from my consult to surgery everyone was soooo sweet and kind! So very helpful from the front desk to the treatment coordinators to the pre op the whole surgery experience to post op!!
If you are considering on having anything done I highly recommend. I am extremely happy with my results so far and it’s only been a week.
Dr. Downs and his staff are amazing!
He took me on as a patient after another surgeon botched me.
Dr. Downs will take the time to review everything with you and let you know what your options are.
His staff are wonderful and they make you feel so comfortable!
You will be in great hands with Dr. Downs and his team!
The medspa staff are always friendly and welcoming. Kellee has the LIGHTEST touch with an injection needle and always does a great job!
Dr. Downs and The Centre, P.C. staff are wonderful to work with for questions/concerns prior to and after surgery during recovery period. Dr. Downs consults with patient prior to surgery to confirm understanding of what results are important to them.
Additionally, Dr. Downs personally follows up after surgery to ensure that things are going well after discharge which I was extremely impressed by. The office/surgical center provides a more discrete and personalized patient environment with a separate door entrance for the follow-up appointment the day after surgery as well.
From the time I walked in the door to the moment I walked out, I felt respected, seen and heard! The staff are kind and gentle and I will never go anywhere else for the things I need. Dr. Macias is outstanding.
Dr. Downs and whole team at Centre PC have been amazing! They listened to me as I told them my desired results, provided different options for me, based on years of industry knowledge and worked alongside me as I navigated the headaches of insurance. I couldn’t be happier with my experience there and would highly recommend them to anyone looking to make some positive change in their life!
I was recently hospitalized last week for a finger infection. I ended up having surgery and Dr. Downs was my doctor. Very good bedside manner and great doctor. He takes his time to explain things to you. I really liked that. And went to his office for my follow up. All the staff were so sweet and professional.
Frequently Asked Questions
About Weight Loss Program in Mishawaka, IN
Treatment duration varies based on your goals, but most patients continue until they achieve their desired weight and transition to a maintenance plan.
Yes, minor dietary and activity adjustments enhance results and minimize side effects.
Your provider will review your current medications to ensure there are no conflicts.

